Note that this item does not protect against clouds of poison gas, such as those from Stink Rays and Poison Holes.
It can be especially helpful to wear the Seashell Suit when chopping Jungle Trees as Poison Snakes may appear.
Keeping a Seashell Suit in the inventory during Monsoon Season can be really handy, since it is a cheap way to protect the character from Poison Mosquitoes. It is also more efficient than carrying an Anti Venom and armor at the same time, saving one inventory slot.
It is recommended to carry a Seashell Suit when gambling at the Slot Machine, since there is a chance to get Poison Snakes or Poison Mosquitoes after a spin.