Just give your best listing of characters (you must have between 2 and 4 people in this group) to have at a base and where the group could set up a base to get the most functionality.
For example (but maybe not as much of a wall of text):
The best group (in my opinion) would consist of Wickerbottom, Webber, and Wigfrid, and would work best in the Desert. Wickerbottom provides early science recipes for the other two people, and can also instantly grow crops, gathering crockpot filler, twigs, grass, and cactus (it is in the desert). Webber can set up a spider nest by the base, providing the two other members with monster meat, silk, and spider glands. Wigfrid specifically can also gain health and sanity from killing spiders. Silk can be used to make tents, which help Wigfrid out tremendously, due to the lack of sanity-restoring meat products. Webber can also use these tents, but will not need to as much as Wigfrid, as Wickerbottom can supply cacti to restore sanity, negating one of Webber's drawbacks. Monster meat can be used with berries to make meatballs, which will be the main source of food among the group. Spider glands can be used unprocessed or as salves to restore health, and can also make telltale hearts in the rare event someone dies. Wigfrid can supply the entire group with battle helms and spears, increasing each individual's defensive and offensive capabilities and reducing casualties greatly. Wigfrid is also a dominant fighter, and can take on bosses with relative ease.
In the end, the group has access to food, sanity, health, weaponry, and cooperation.